San Francisco Frontiers - Winless NFL run by 49ers ends at Cleveland

The blow of that defeat, the first as an NFL starter for quarterback Brock Purdy, was even heavier for the 49ers, with star running backs Christian McCaffrey and Deebo Samuel both leaving the game with injuries.

Going into the game on the back of five straight wins, including last week's 42-10 trouncing of the Dallas Cowboys, the 'Niners were heavily favored against a Browns team with just one victory.

McCaffrey scored from a 13-yard Purdy pass to put San Francisco ahead in the first quarter and a 25-yard Moody field goal made it 10-0.

But the Browns fought back, with a 16-yard touchdown run from Kareem Hunt and took the lead after two field goals in the third quarter by Dustin Hopkins.

The 49ers restored their lead early in the fourth with an eight-yard touchdown rush from Jordan Mason before two field goals from Hopkins secured the upset triumph.

Purdy managed just 125 yards on 12 of 27 passing with one interception and one touchdown.

At Miami, Tua Tagovailoa threw for three touchdowns and 262 yards as the Miami Dolphins again showed the power of their offense, improving to 5-1 with a 42-21 victory over the winless Carolina Panthers.

The Panthers opened a 14-0 lead with two touchdowns in the first quarter before the Dolphins turned on the style.

Tyreek Hill had 163 yards receiving, including a 41-yard touchdown catch late in the third to put the Dolphins ahead 21-14.

Raheem Mostert then ran in two touchdowns for Miami before Tagovailoa was taken out of the game and his back-up, Mike White, threw an interception that was returned 61 yards for a touchdown by Troy Hill.

But Miami's ability on the ground, as well the air, was demonstrated again with Salvon Ahmed rushing in from nine yards to wrap up the win.

Washington Commanders quarterback Sam Howell threw three touchdown passes in a 24-16 win over the Atlanta Falcons, which improved the Commanders to 3-3.

Desmond Ridder, the Falcons quarterback, threw two touchdowns -- the second a two-yard toss to Jonnu Smith that reduced the deficit to eight points.

But Ridder then threw two interceptions to end any hope of an Atlanta comeback.

The Cincinnati Bengals defense came up big in a 17-13 win over the Seattle Seahawks.

Seattle quarterback Geno Smith threw two interceptions in the second half and the Bengals defense stopped the Seahawks twice deep in Cincinnati territory late in the game.

In London, the Baltimore Ravens beat the Tennessee Titans 24-16 at Tottenham Hotspur Stadium, with Justin Tucker kicking six field goals.

M.Gonzalez--SFF